Cytomegalovirus

A Safdar, D Armstrong - Principles and practice of transplant infectious …, 2019 - Springer
… of the CMV viral load in the peripheral blood. A positive … therapy, a genetic drug mutation
analysis should be performed. This is … therapy for CMV retinitis in patients with HIV/AIDS [207]. …

Clinical pharmacokinetic monitoring and resistance testing for the optimisation of antiviral therapy targeting human cytomegalovirus

D Wong - 2022 - unsworks.unsw.edu.au
… novel ganciclovir-resistant mutations examined in this study ....… analysis of a patient specimen
with sufficient viral load. The … with valganciclovir for CMV retinitis in AIDS patients [191]. The …

[HTML][HTML] Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
… about serial measures of the viral load to explain features of … an enlarged T cell compartment
dominated by anti-HCMV T … commonly used to treat ganciclovir-resistant strains of HCMV, …

Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance

S Chou - Antiviral research, 2020 - Elsevier
… in components of the terminase complex responsible for cleavage of freshly replicated …
readout of mutations shown to knock out viral viability in 9 specimens with a median viral load of …

Advances in the development of therapeutics for cytomegalovirus infections

E Acosta, T Bowlin, J Brooks, L Chiang… - The Journal of …, 2020 - academic.oup.com
CMV [60], and retained activity against ganciclovir-resistant isolates of CMV having mutations
… , foretelling significant patient benefits of improved control of viral load, minimized adverse …

CMV infection management in transplant patients in Italy

PA Grossi, F Baldanti, M Andreoni, CF Perno - Journal of Clinical Virology, 2020 - Elsevier
… Time-PCR assays has unravelled the potential of viral load … The resistance may be caused
by genetic mutations of the virus, or … the viral kinetic is similar in both compartments, CMV is …

[HTML][HTML] Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighting the Role of Advanced Practice Providers …

WV Cochran, MV Dioverti, J Langlee… - Annals of …, 2024 - ncbi.nlm.nih.gov
… , longitudinal study in the USA, where multiple-course anti-… of CMV viral load is often used
to diagnose CMV infection, … recipients with ganciclovir-resistant or refractory CMV infection, 5 (…

Cytomegalovirus in hematopoietic stem cell transplant recipients: prevention, diagnosis, and treatment

JF Camargo - Emerging transplant infections: clinical challenges and …, 2021 - Springer
… 40% of patients achieving a plasma viral load of more than … , except that known genetic
mutations conferring resistance are … patients with recurrent or ganciclovir-resistant CMV infection, …

Human6A, 6B, and Herpesviruses7

H Agut, P Bonnafous… - … Microbiology of the …, 2020 - books.google.com
… and decrease of viral load, as in the case of anti-CMV treatments (110… in case of longitudinal
follow-up. Note that, in ciHHV-6 … Human herpesvirus 6 ganciclovir-resistant strain with amino …

[HTML][HTML] The CD4+ T cell response to human cytomegalovirus in healthy and immunocompromised people

EY Lim, SE Jackson, MR Wills - Frontiers in cellular and infection …, 2020 - frontiersin.org
… the adaptive immune response to viruses and other pathogens. … CMV retinitis with 14 patients
who did not showed that the … CMV antigens, had lower peak CMV viral loads compared to …